Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 208279..209111 Replicon chromosome
Accession NZ_CP116976
Organism Escherichia coli strain CUVM53

Toxin (Protein)


Gene name yeeV Uniprot ID F4TJC5
Locus tag PQP10_RS01010 Protein ID WP_001094452.1
Coordinates 208737..209111 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PQP10_RS01005 Protein ID WP_112019398.1
Coordinates 208279..208647 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP10_RS00980 (205375) 205375..205570 + 196 Protein_193 DUF905 family protein -
PQP10_RS00985 (205687) 205687..206505 + 819 WP_075362641.1 DUF932 domain-containing protein -
PQP10_RS00990 (206847) 206847..207320 + 474 WP_075362640.1 antirestriction protein -
PQP10_RS00995 (207336) 207336..207812 + 477 WP_001186770.1 RadC family protein -
PQP10_RS01000 (207881) 207881..208102 + 222 WP_000692300.1 DUF987 domain-containing protein -
PQP10_RS01005 (208279) 208279..208647 + 369 WP_112019398.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PQP10_RS01010 (208737) 208737..209111 + 375 WP_001094452.1 TA system toxin CbtA family protein Toxin
PQP10_RS01015 (209108) 209108..209599 + 492 WP_143359947.1 DUF5983 family protein -
PQP10_RS01020 (209611) 209611..209808 + 198 WP_000772035.1 DUF957 domain-containing protein -
PQP10_RS01025 (209905) 209905..210747 + 843 WP_063082311.1 DUF4942 domain-containing protein -
PQP10_RS01035 (211218) 211218..212156 + 939 WP_000351315.1 glyoxylate/hydroxypyruvate reductase GhrA -
PQP10_RS01040 (212211) 212211..212948 + 738 WP_000283664.1 zinc-binding phosphatase -
PQP10_RS01045 (212972) 212972..213526 + 555 WP_001001902.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14014.86 Da        Isoelectric Point: 7.2920

>T269587 WP_001094452.1 NZ_CP116976:208737-209111 [Escherichia coli]
MNTLPDTHVREASRCSSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSTDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13660.52 Da        Isoelectric Point: 7.3712

>AT269587 WP_112019398.1 NZ_CP116976:208279-208647 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z7YIM6

Antitoxin

Source ID Structure

References