Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pCUVM3.2
Accession NZ_CP116972
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PQP09_RS24980 Protein ID WP_244442846.1
Coordinates 2255..2533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag PQP09_RS24975 Protein ID WP_000079941.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS24965 (46) 46..1077 + 1032 WP_000907873.1 plasmid replication initiator RepA -
PQP09_RS24970 (1773) 1773..1931 + 159 WP_000841008.1 hypothetical protein -
PQP09_RS24975 (1986) 1986..2255 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PQP09_RS24980 (2255) 2255..2533 + 279 WP_244442846.1 type II toxin-antitoxin system toxin YacB Toxin
PQP09_RS24985 (2573) 2573..3421 + 849 WP_001057991.1 3'-5' exonuclease -
PQP09_RS24990 (3538) 3538..3729 + 192 Protein_5 hypothetical protein -
PQP09_RS24995 (3823) 3823..4203 + 381 WP_001171554.1 transposase -
PQP09_RS25000 (4200) 4200..4547 + 348 WP_000612591.1 IS66 family insertion sequence element accessory protein TnpB -
PQP09_RS25005 (4597) 4597..6135 + 1539 WP_000997962.1 IS66-like element ISEc8 family transposase -
PQP09_RS25010 (6249) 6249..6461 + 213 WP_032151770.1 hypothetical protein -
PQP09_RS25015 (6938) 6938..7204 - 267 WP_000955263.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..101216 101216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10761.43 Da        Isoelectric Point: 9.7617

>T269579 WP_244442846.1 NZ_CP116972:2255-2533 [Escherichia coli]
MEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT269579 WP_000079941.1 NZ_CP116972:1986-2255 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References