Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 103449..104074 Replicon plasmid pCUVM3.1
Accession NZ_CP116971
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PQP09_RS24595 Protein ID WP_000911313.1
Coordinates 103676..104074 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag PQP09_RS24590 Protein ID WP_000450532.1
Coordinates 103449..103676 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS24590 (103449) 103449..103676 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP09_RS24595 (103676) 103676..104074 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP09_RS24600 (104083) 104083..106236 - 2154 WP_072664524.1 type IV conjugative transfer system coupling protein TraD -
PQP09_RS24605 (106489) 106489..107220 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PQP09_RS24610 (107252) 107252..107749 - 498 WP_000605859.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..164599 164599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T269574 WP_000911313.1 NZ_CP116971:103676-104074 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT269574 WP_000450532.1 NZ_CP116971:103449-103676 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References