Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4362948..4363566 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PQP09_RS21470 Protein ID WP_001291435.1
Coordinates 4362948..4363166 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PQP09_RS21475 Protein ID WP_000344800.1
Coordinates 4363192..4363566 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS21435 (4358237) 4358237..4358809 + 573 WP_000779826.1 YbaY family lipoprotein -
PQP09_RS21440 (4358840) 4358840..4359151 - 312 WP_000409911.1 MGMT family protein -
PQP09_RS21450 (4359530) 4359530..4359883 + 354 WP_000878141.1 DUF1428 family protein -
PQP09_RS21455 (4359925) 4359925..4361475 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PQP09_RS21460 (4361639) 4361639..4362109 - 471 WP_000136192.1 YlaC family protein -
PQP09_RS21465 (4362225) 4362225..4362776 - 552 WP_000102564.1 maltose O-acetyltransferase -
PQP09_RS21470 (4362948) 4362948..4363166 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PQP09_RS21475 (4363192) 4363192..4363566 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PQP09_RS21480 (4364112) 4364112..4367261 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PQP09_RS21485 (4367284) 4367284..4368477 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269571 WP_001291435.1 NZ_CP116970:c4363166-4362948 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269571 WP_000344800.1 NZ_CP116970:c4363566-4363192 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References