269570

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 4328651..4329488 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag PQP09_RS21300 Protein ID WP_096262872.1
Coordinates 4328651..4329193 (-) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PQP09_RS21305 Protein ID WP_001297137.1
Coordinates 4329177..4329488 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS21280 (4324190) 4324190..4325101 - 912 WP_000705874.1 2-dehydropantoate 2-reductase -
PQP09_RS21285 (4325269) 4325269..4325760 + 492 WP_001138904.1 nucleotide binding protein YajQ -
PQP09_RS21290 (4325888) 4325888..4327252 - 1365 WP_001000978.1 MFS transporter -
PQP09_RS21295 (4327660) 4327660..4328595 + 936 WP_001297127.1 tetratricopeptide repeat protein -
PQP09_RS21300 (4328651) 4328651..4329193 - 543 WP_096262872.1 GNAT family N-acetyltransferase Toxin
PQP09_RS21305 (4329177) 4329177..4329488 - 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PQP09_RS21310 (4329673) 4329673..4330563 - 891 WP_000971336.1 heme o synthase -
PQP09_RS21315 (4330575) 4330575..4330904 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PQP09_RS21320 (4330904) 4330904..4331518 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PQP09_RS21325 (4331508) 4331508..4333499 - 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PQP09_RS21330 (4333521) 4333521..4334468 - 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19804.03 Da        Isoelectric Point: 8.6178

>T269570 WP_096262872.1 NZ_CP116970:c4329193-4328651 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSNITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT269570 WP_001297137.1 NZ_CP116970:c4329488-4329177 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References