Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2797804..2798435 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag PQP09_RS14040 Protein ID WP_001259385.1
Coordinates 2798160..2798435 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q31VE4
Locus tag PQP09_RS14035 Protein ID WP_000593554.1
Coordinates 2797804..2798163 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS14005 (2792916) 2792916..2793389 + 474 WP_001161553.1 PTS sugar transporter subunit IIA -
PQP09_RS14010 (2793386) 2793386..2793667 + 282 WP_000084022.1 PTS sugar transporter subunit IIB -
PQP09_RS14015 (2793744) 2793744..2795102 + 1359 WP_001298729.1 PTS galactitol transporter subunit IIC -
PQP09_RS14020 (2795095) 2795095..2796603 + 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
PQP09_RS14025 (2796593) 2796593..2796862 + 270 WP_000933060.1 HPr family phosphocarrier protein -
PQP09_RS14030 (2796894) 2796894..2797754 + 861 WP_001131782.1 class II aldolase -
PQP09_RS14035 (2797804) 2797804..2798163 - 360 WP_000593554.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PQP09_RS14040 (2798160) 2798160..2798435 - 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
PQP09_RS14045 (2798508) 2798508..2799632 - 1125 WP_001314210.1 ABC transporter permease -
PQP09_RS14050 (2799632) 2799632..2802367 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
PQP09_RS14055 (2802364) 2802364..2803431 - 1068 WP_000361467.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T269565 WP_001259385.1 NZ_CP116970:c2798435-2798160 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13359.25 Da        Isoelectric Point: 4.8838

>AT269565 WP_000593554.1 NZ_CP116970:c2798163-2797804 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H2GM94

References