Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2770562..2771362 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag PQP09_RS13880 Protein ID WP_000342449.1
Coordinates 2770562..2771089 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag PQP09_RS13885 Protein ID WP_001277108.1
Coordinates 2771096..2771362 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS13855 (2765637) 2765637..2766404 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PQP09_RS13860 (2766401) 2766401..2767678 - 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
PQP09_RS13865 (2767675) 2767675..2768601 - 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PQP09_RS13870 (2768649) 2768649..2769758 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PQP09_RS13875 (2770182) 2770182..2770565 + 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
PQP09_RS13880 (2770562) 2770562..2771089 - 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PQP09_RS13885 (2771096) 2771096..2771362 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PQP09_RS13890 (2771512) 2771512..2772615 - 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PQP09_RS13895 (2772886) 2772886..2773740 - 855 WP_000130221.1 RNA polymerase sigma factor RpoH -
PQP09_RS13900 (2773985) 2773985..2775043 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
PQP09_RS13905 (2775036) 2775036..2775704 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T269564 WP_000342449.1 NZ_CP116970:c2771089-2770562 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT269564 WP_001277108.1 NZ_CP116970:c2771362-2771096 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References