Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2198742..2199396 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PQP09_RS11005 Protein ID WP_000244781.1
Coordinates 2198742..2199149 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag PQP09_RS11010 Protein ID WP_139501106.1
Coordinates 2199130..2199396 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS10985 (2194699) 2194699..2196432 - 1734 WP_096262898.1 single-stranded-DNA-specific exonuclease RecJ -
PQP09_RS10990 (2196438) 2196438..2197148 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP09_RS10995 (2197173) 2197173..2198069 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PQP09_RS11000 (2198181) 2198181..2198702 + 522 WP_001055874.1 flavodoxin FldB -
PQP09_RS11005 (2198742) 2198742..2199149 - 408 WP_000244781.1 protein YgfX Toxin
PQP09_RS11010 (2199130) 2199130..2199396 - 267 WP_139501106.1 FAD assembly factor SdhE Antitoxin
PQP09_RS11015 (2199639) 2199639..2200619 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
PQP09_RS11020 (2200696) 2200696..2201355 - 660 WP_000250274.1 hemolysin III family protein -
PQP09_RS11025 (2201519) 2201519..2201830 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
PQP09_RS11030 (2201875) 2201875..2203308 + 1434 WP_139501107.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T269562 WP_000244781.1 NZ_CP116970:c2199149-2198742 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10494.07 Da        Isoelectric Point: 4.8726

>AT269562 WP_139501106.1 NZ_CP116970:c2199396-2199130 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFICLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure

References