Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1731287..1731912 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PQP09_RS08730 Protein ID WP_000911329.1
Coordinates 1731287..1731685 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PQP09_RS08735 Protein ID WP_000450524.1
Coordinates 1731685..1731912 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS08710 (1727165) 1727165..1727365 + 201 WP_000383836.1 YpfN family protein -
PQP09_RS08715 (1727475) 1727475..1728173 - 699 WP_000679812.1 esterase -
PQP09_RS08720 (1728247) 1728247..1730262 - 2016 WP_000829393.1 tRNA cytosine(34) acetyltransferase TmcA -
PQP09_RS08725 (1730277) 1730277..1731140 - 864 WP_112021547.1 neutral zinc metallopeptidase -
PQP09_RS08730 (1731287) 1731287..1731685 - 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PQP09_RS08735 (1731685) 1731685..1731912 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PQP09_RS08740 (1732067) 1732067..1732780 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PQP09_RS08745 (1732993) 1732993..1734027 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PQP09_RS08750 (1734044) 1734044..1734922 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PQP09_RS08755 (1735068) 1735068..1735640 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PQP09_RS08760 (1735640) 1735640..1736110 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T269560 WP_000911329.1 NZ_CP116970:c1731685-1731287 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT269560 WP_000450524.1 NZ_CP116970:c1731912-1731685 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References