Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 741107..741745 Replicon chromosome
Accession NZ_CP116970
Organism Escherichia coli strain CUVM3

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PQP09_RS03575 Protein ID WP_000813794.1
Coordinates 741569..741745 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PQP09_RS03570 Protein ID WP_001270286.1
Coordinates 741107..741523 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP09_RS03550 (736259) 736259..737200 - 942 WP_001251315.1 ABC transporter permease -
PQP09_RS03555 (737201) 737201..738214 - 1014 WP_000220411.1 ABC transporter ATP-binding protein -
PQP09_RS03560 (738232) 738232..739377 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
PQP09_RS03565 (739622) 739622..741028 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
PQP09_RS03570 (741107) 741107..741523 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PQP09_RS03575 (741569) 741569..741745 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PQP09_RS03580 (741967) 741967..742197 + 231 WP_000494239.1 YncJ family protein -
PQP09_RS03585 (742289) 742289..744250 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PQP09_RS03590 (744323) 744323..744859 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PQP09_RS03595 (744951) 744951..746126 + 1176 WP_001236258.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T269559 WP_000813794.1 NZ_CP116970:c741745-741569 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269559 WP_001270286.1 NZ_CP116970:c741523-741107 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References