269553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 12173..13310 Replicon plasmid pDM86-poxtA
Accession NZ_CP116965
Organism Enterococcus faecalis strain DM86

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag PO880_RS15230 Protein ID WP_100185210.1
Coordinates 12447..13310 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag PO880_RS15225 Protein ID WP_000301765.1
Coordinates 12173..12445 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO880_RS15200 (PO880_15200) 7898..8068 + 171 WP_000713595.1 hypothetical protein -
PO880_RS15205 (PO880_15205) 8082..8699 + 618 WP_002295591.1 recombinase family protein -
PO880_RS15210 (PO880_15210) 8699..10843 + 2145 WP_225001404.1 type IA DNA topoisomerase -
PO880_RS15215 (PO880_15215) 10946..11842 + 897 WP_002304405.1 ParA family protein -
PO880_RS15220 (PO880_15220) 11941..12156 + 216 WP_002295735.1 peptide-binding protein -
PO880_RS15225 (PO880_15225) 12173..12445 + 273 WP_000301765.1 antitoxin Antitoxin
PO880_RS15230 (PO880_15230) 12447..13310 + 864 WP_100185210.1 zeta toxin family protein Toxin
PO880_RS15235 (PO880_15235) 13751..14068 + 318 WP_002338433.1 hypothetical protein -
PO880_RS15240 (PO880_15240) 14088..14585 + 498 WP_010713926.1 molecular chaperone DnaJ -
PO880_RS15245 (PO880_15245) 14619..14924 + 306 WP_070544069.1 hypothetical protein -
PO880_RS15250 (PO880_15250) 14947..15204 - 258 WP_000002668.1 hypothetical protein -
PO880_RS15255 (PO880_15255) 15207..15506 - 300 WP_002325624.1 hypothetical protein -
PO880_RS15260 (PO880_15260) 15789..17783 + 1995 WP_272731748.1 MobQ family relaxase -
PO880_RS15265 (PO880_15265) 17807..18139 + 333 WP_000713503.1 CagC family type IV secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid poxtA / Cfr(D) - 1..33351 33351


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32416.95 Da        Isoelectric Point: 6.6610

>T269553 WP_100185210.1 NZ_CP116965:12447-13310 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT269553 WP_000301765.1 NZ_CP116965:12173-12445 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References