Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 276500..277071 Replicon chromosome
Accession NZ_CP116962
Organism Enterococcus faecalis strain DM86

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PO880_RS01290 Protein ID WP_010710856.1
Coordinates 276730..277071 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PO880_RS01285 Protein ID WP_002354773.1
Coordinates 276500..276730 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO880_RS01265 (271717) 271717..273333 - 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -
PO880_RS01270 (274018) 274018..274656 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
PO880_RS01275 (274823) 274823..275815 - 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
PO880_RS01280 (275954) 275954..276169 + 216 WP_002354768.1 zinc ribbon domain-containing protein -
PO880_RS01285 (276500) 276500..276730 + 231 WP_002354773.1 hypothetical protein Antitoxin
PO880_RS01290 (276730) 276730..277071 + 342 WP_010710856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PO880_RS01295 (277442) 277442..281056 + 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13177.47 Da        Isoelectric Point: 9.3988

>T269532 WP_010710856.1 NZ_CP116962:276730-277071 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPIISTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT269532 WP_002354773.1 NZ_CP116962:276500-276730 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References