Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/-
Location 1277131..1278224 Replicon chromosome
Accession NZ_CP116958
Organism Streptococcus pasteurianus strain WUSP074

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag M0P28_RS06575 Protein ID WP_000233000.1
Coordinates 1277131..1278000 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag M0P28_RS06580 Protein ID WP_044720927.1
Coordinates 1278015..1278224 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0P28_RS06545 (M0P28_06545) 1272255..1272926 - 672 WP_044720945.1 Rep family protein -
M0P28_RS06550 (M0P28_06550) 1273498..1273905 - 408 WP_235809127.1 hypothetical protein -
M0P28_RS06555 (M0P28_06555) 1274334..1275071 - 738 WP_002321849.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M0P28_RS06560 (M0P28_06560) 1275196..1275279 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
M0P28_RS06565 (M0P28_06565) 1275520..1276383 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M0P28_RS06570 (M0P28_06570) 1276416..1277150 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M0P28_RS06575 (M0P28_06575) 1277131..1278000 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
M0P28_RS06580 (M0P28_06580) 1278015..1278224 - 210 WP_044720927.1 helix-turn-helix transcriptional regulator Antitoxin
M0P28_RS06585 (M0P28_06585) 1278546..1279349 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M0P28_RS06590 (M0P28_06590) 1279403..1280887 - 1485 WP_044720925.1 ABC-F type ribosomal protection protein Lsa(E) -
M0P28_RS06595 (M0P28_06595) 1281379..1282941 - 1563 WP_117479901.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn tet(L) / tet(O/W/32/O) / erm(B) / ant(6)-Ia / lnu(B) / lsa(E) - 1258701..1280887 22186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-52)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T269524 WP_000233000.1 NZ_CP116958:c1278000-1277131 [Streptococcus pasteurianus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7832.08 Da        Isoelectric Point: 4.7228

>AT269524 WP_044720927.1 NZ_CP116958:c1278224-1278015 [Streptococcus pasteurianus]
MIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References