Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1045361..1045877 Replicon chromosome
Accession NZ_CP116958
Organism Streptococcus pasteurianus strain WUSP074

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag M0P28_RS05405 Protein ID WP_014620143.1
Coordinates 1045361..1045618 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID -
Locus tag M0P28_RS05410 Protein ID WP_117479834.1
Coordinates 1045611..1045877 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0P28_RS05380 (M0P28_05380) 1040745..1041443 + 699 WP_117479843.1 GntR family transcriptional regulator -
M0P28_RS05385 (M0P28_05385) 1041687..1042535 - 849 WP_117479841.1 MurR/RpiR family transcriptional regulator -
M0P28_RS05390 (M0P28_05390) 1042717..1043688 + 972 WP_274513105.1 Gfo/Idh/MocA family oxidoreductase -
M0P28_RS05395 (M0P28_05395) 1043693..1044217 + 525 WP_117479838.1 heme-binding protein -
M0P28_RS05400 (M0P28_05400) 1044238..1045296 + 1059 WP_117479836.1 Gfo/Idh/MocA family oxidoreductase -
M0P28_RS05405 (M0P28_05405) 1045361..1045618 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
M0P28_RS05410 (M0P28_05410) 1045611..1045877 - 267 WP_117479834.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M0P28_RS05415 (M0P28_05415) 1046041..1046373 + 333 WP_117479832.1 putative DNA-binding protein -
M0P28_RS05420 (M0P28_05420) 1046444..1048009 + 1566 WP_117479830.1 signal recognition particle protein -
M0P28_RS05425 (M0P28_05425) 1048075..1049091 - 1017 WP_117479828.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T269523 WP_014620143.1 NZ_CP116958:c1045618-1045361 [Streptococcus pasteurianus]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10364.61 Da        Isoelectric Point: 4.4734

>AT269523 WP_117479834.1 NZ_CP116958:c1045877-1045611 [Streptococcus pasteurianus]
MEAVAYSNFRQNLKYYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMSKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure

References