269522

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1494742..1495228 Replicon chromosome
Accession NZ_CP116957
Organism Streptococcus pasteurianus strain WUSP070

Toxin (Protein)


Gene name relE Uniprot ID F5X5E2
Locus tag M0P24_RS07460 Protein ID WP_013851589.1
Coordinates 1494742..1495011 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5X5E1
Locus tag M0P24_RS07465 Protein ID WP_013851588.1
Coordinates 1495001..1495228 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0P24_RS07440 (M0P24_07440) 1492177..1492731 - 555 WP_013851590.1 hypothetical protein -
M0P24_RS07445 (M0P24_07445) 1492928..1493449 - 522 WP_003063789.1 transcription repressor NadR -
M0P24_RS07450 (M0P24_07450) 1493861..1494073 + 213 WP_231844751.1 DUF3267 domain-containing protein -
M0P24_RS07455 (M0P24_07455) 1494101..1494265 + 165 WP_231844750.1 hypothetical protein -
M0P24_RS07460 (M0P24_07460) 1494742..1495011 - 270 WP_013851589.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0P24_RS07465 (M0P24_07465) 1495001..1495228 - 228 WP_013851588.1 DUF6290 family protein Antitoxin
M0P24_RS07470 (M0P24_07470) 1495861..1496073 - 213 WP_069789057.1 hypothetical protein -
M0P24_RS07475 (M0P24_07475) 1496133..1496594 - 462 WP_069789056.1 hypothetical protein -
M0P24_RS07480 (M0P24_07480) 1496920..1497351 - 432 WP_061100156.1 ArpU family phage packaging/lysis transcriptional regulator -
M0P24_RS07485 (M0P24_07485) 1497372..1497962 - 591 WP_248497809.1 hypothetical protein -
M0P24_RS07490 (M0P24_07490) 1498209..1498511 - 303 WP_069789038.1 hypothetical protein -
M0P24_RS07495 (M0P24_07495) 1498671..1499516 - 846 WP_248497811.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1484040..1583716 99676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10500.51 Da        Isoelectric Point: 10.4700

>T269522 WP_013851589.1 NZ_CP116957:c1495011-1494742 [Streptococcus pasteurianus]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGVENPRQMGKALTGQFKGLWRYRIGNYRVICDIIDDDLVILAIEV
GHRKDIYKN

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8675.72 Da        Isoelectric Point: 4.2808

>AT269522 WP_013851588.1 NZ_CP116957:c1495228-1495001 [Streptococcus pasteurianus]
MSIVSLRLNKNEEELFKSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALNEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A135YV33

Antitoxin

Source ID Structure
AlphaFold DB A0A135YV28

References