269521

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/-
Location 856221..857314 Replicon chromosome
Accession NZ_CP116957
Organism Streptococcus pasteurianus strain WUSP070

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag M0P24_RS04310 Protein ID WP_000233000.1
Coordinates 856445..857314 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag M0P24_RS04305 Protein ID WP_044720927.1
Coordinates 856221..856430 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0P24_RS04290 (M0P24_04290) 851918..853066 + 1149 Protein_852 recombinase family protein -
M0P24_RS04295 (M0P24_04295) 853558..855042 + 1485 WP_044720925.1 ABC-F type ribosomal protection protein Lsa(E) -
M0P24_RS04300 (M0P24_04300) 855096..855899 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
M0P24_RS04305 (M0P24_04305) 856221..856430 + 210 WP_044720927.1 helix-turn-helix transcriptional regulator Antitoxin
M0P24_RS04310 (M0P24_04310) 856445..857314 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
M0P24_RS04315 (M0P24_04315) 857295..858029 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
M0P24_RS04320 (M0P24_04320) 858062..858925 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
M0P24_RS04325 (M0P24_04325) 859166..859249 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
M0P24_RS04330 (M0P24_04330) 859374..860111 + 738 WP_001038796.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
M0P24_RS04335 (M0P24_04335) 860540..860947 + 408 WP_235809127.1 hypothetical protein -
M0P24_RS04340 (M0P24_04340) 861539..862210 + 672 WP_044720945.1 Rep family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(6')-aph(2'') / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) / tet(O/W/32/O) / tet(L) - 809861..881533 71672
- inside IScluster/Tn aac(6')-aph(2'') / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) / tet(O/W/32/O) / tet(L) - 845234..868250 23016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-52)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T269521 WP_000233000.1 NZ_CP116957:856445-857314 [Streptococcus pasteurianus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7832.08 Da        Isoelectric Point: 4.7228

>AT269521 WP_044720927.1 NZ_CP116957:856221-856430 [Streptococcus pasteurianus]
MIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References