Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 51135..52863 Replicon plasmid p2939_90_1
Accession NZ_CP116944
Organism Providencia alcalifaciens strain 2939/90

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag PO864_RS19680 Protein ID WP_036961062.1
Coordinates 51135..52079 (-) Length 315 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag PO864_RS19685 Protein ID WP_036961064.1
Coordinates 52072..52863 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO864_RS19660 (PO864_19860) 48131..48856 - 726 WP_051420265.1 tyrosine-type recombinase/integrase -
PO864_RS19665 (PO864_19865) 49411..49944 - 534 Protein_32 Fic family protein -
PO864_RS19670 (PO864_19870) 50111..50398 - 288 WP_262362005.1 DUF6216 family protein -
PO864_RS19675 (PO864_19875) 50668..50943 - 276 WP_036961060.1 hypothetical protein -
PO864_RS19680 (PO864_19880) 51135..52079 - 945 WP_036961062.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PO864_RS19685 (PO864_19885) 52072..52863 - 792 WP_036961064.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PO864_RS19690 (PO864_19890) 53259..53420 - 162 Protein_37 DUF2913 family protein -
PO864_RS19695 (PO864_19895) 53428..53751 - 324 WP_282490728.1 ProQ/FINO family protein -
PO864_RS19700 (PO864_19900) 53802..54008 - 207 WP_036961068.1 hypothetical protein -
PO864_RS19705 (PO864_19905) 54923..55648 - 726 WP_036961071.1 RepA family replication protein -
PO864_RS19710 (PO864_19910) 56057..56536 - 480 WP_148484542.1 hypothetical protein -
PO864_RS19715 (PO864_19915) 56552..57070 - 519 WP_051459659.1 conjugative transfer relaxase/helicase TraI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - sicA / spaS / spaQ / spaP / invC/sctN / invA / espC / prgK / prgI 1..127696 127696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(19-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 315 a.a.        Molecular weight: 35744.32 Da        Isoelectric Point: 4.9748

>T269518 WP_036961062.1 NZ_CP116944:c52079-51135 [Providencia alcalifaciens]
MDRDSPYYKQVSLLIKMLPVIATEPTFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNDALVNVKAALLRLTELINTQ
VDTRAVLQDHKVDELRIIVTSPDGTIKVEVSPVARGTLHQPRILSVQPSVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVHMLLTEEGISRDIFIGFLTYVLSHPRPINEVMDPNWKPLDQTFQTEFDGMTLVNIELEDLIAVRLAMMSALQA
HFTEKDRAFLLSFKQGKPDWALFDYPSAEGLPAIRWKLQNIAQLAKNQDKYTEQLSKLEVVLDRWIYLADKQKL

Download         Length: 945 bp

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30154.44 Da        Isoelectric Point: 9.5728

>AT269518 WP_036961064.1 NZ_CP116944:c52863-52072 [Providencia alcalifaciens]
MSSKINWLITHTSPGSIVLQQWLTKNGVSYSLAQKYTQSGWLKKLFSGVYYRPDGKDGTKPDWVDALQAMDIQLCLPVHL
AGLSSLNYQGLSHYLQLRKEQVWVSVKSKQSLPKWFREFPNQDWFYCGNSKFQVAPDMDLKFITVKGKELLASRPELAAY
EVIDAIGKQISFEHAAELFQGLVNLSPKRVQSLLERSHAIQTNRIFLFLSHHCGHQWAQRLNETNIELGSGKRQVVEKGR
FDERYQITVPESLNAKQEEQKNG

Download         Length: 792 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References