Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2297093..2297737 Replicon chromosome
Accession NZ_CP116943
Organism Providencia alcalifaciens strain 2939/90

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag PO864_RS10715 Protein ID WP_004905417.1
Coordinates 2297093..2297296 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PO864_RS10720 Protein ID WP_006662760.1
Coordinates 2297369..2297737 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO864_RS10695 (PO864_10795) 2292986..2294767 + 1782 WP_036961890.1 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein -
PO864_RS10700 (PO864_10800) 2294914..2295780 - 867 WP_036961892.1 acyl-CoA thioesterase II -
PO864_RS10705 2296187..2296396 + 210 Protein_2081 YbaY family lipoprotein -
PO864_RS10715 (PO864_10815) 2297093..2297296 - 204 WP_004905417.1 HHA domain-containing protein Toxin
PO864_RS10720 (PO864_10820) 2297369..2297737 - 369 WP_006662760.1 Hha toxicity modulator TomB Antitoxin
PO864_RS10725 (PO864_10825) 2298263..2299642 - 1380 WP_036961894.1 murein transglycosylase D -
PO864_RS10730 (PO864_10830) 2299698..2300477 - 780 WP_282490042.1 hydroxyacylglutathione hydrolase -
PO864_RS10735 (PO864_10835) 2300514..2301239 + 726 WP_006657235.1 methyltransferase domain-containing protein -
PO864_RS10740 (PO864_10840) 2301243..2301722 - 480 WP_282490043.1 ribonuclease HI -
PO864_RS10745 (PO864_10845) 2301777..2302538 + 762 WP_036961895.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T269517 WP_004905417.1 NZ_CP116943:c2297296-2297093 [Providencia alcalifaciens]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14087.96 Da        Isoelectric Point: 4.4687

>AT269517 WP_006662760.1 NZ_CP116943:c2297737-2297369 [Providencia alcalifaciens]
MDEYSPKKHDIAELKYLCNSLNRDAISSLQKTNTHWINDLSSAQSISLNELVEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYNLFGSPVVTFSEIIDWESMNQNLVAVLDDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References