269516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1436283..1437202 Replicon chromosome
Accession NZ_CP116941
Organism Bacillus licheniformis strain GN02

Toxin (Protein)


Gene name spoIISA Uniprot ID T5HIF3
Locus tag OSR41_RS07390 Protein ID WP_003180879.1
Coordinates 1436456..1437202 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID T5HT37
Locus tag OSR41_RS07385 Protein ID WP_003180877.1
Coordinates 1436283..1436456 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSR41_RS07360 (OSR41_07360) 1431708..1432805 + 1098 WP_003180867.1 mannonate dehydratase -
OSR41_RS07365 (OSR41_07365) 1432781..1433629 + 849 WP_009328728.1 SDR family oxidoreductase -
OSR41_RS07370 (OSR41_07370) 1433656..1434669 + 1014 WP_003180872.1 zinc-binding alcohol dehydrogenase family protein -
OSR41_RS07375 (OSR41_07375) 1434722..1435993 + 1272 WP_011197811.1 MFS transporter -
OSR41_RS07380 (OSR41_07380) 1436056..1436187 - 132 WP_003180875.1 hypothetical protein -
OSR41_RS07385 (OSR41_07385) 1436283..1436456 - 174 WP_003180877.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
OSR41_RS07390 (OSR41_07390) 1436456..1437202 - 747 WP_003180879.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OSR41_RS07395 (OSR41_07395) 1437313..1438311 - 999 WP_009328723.1 inorganic phosphate transporter -
OSR41_RS07400 (OSR41_07400) 1438324..1438941 - 618 WP_003180884.1 DUF47 domain-containing protein -
OSR41_RS07405 (OSR41_07405) 1439273..1441030 + 1758 WP_003180886.1 gamma-glutamyltransferase -
OSR41_RS07410 (OSR41_07410) 1441159..1441803 + 645 WP_009328721.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29391.80 Da        Isoelectric Point: 4.5367

>T269516 WP_003180879.1 NZ_CP116941:c1437202-1436456 [Bacillus licheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKQLAEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLDRKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6945.04 Da        Isoelectric Point: 10.9186

>AT269516 WP_003180877.1 NZ_CP116941:c1436456-1436283 [Bacillus licheniformis]
MEPAFQQDQESVKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T5HIF3

Antitoxin

Source ID Structure
AlphaFold DB T5HT37

References