Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 559284..559920 Replicon chromosome
Accession NZ_CP116941
Organism Bacillus licheniformis strain GN02

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag OSR41_RS02780 Protein ID WP_003179128.1
Coordinates 559570..559920 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag OSR41_RS02775 Protein ID WP_006638778.1
Coordinates 559284..559565 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSR41_RS02755 (OSR41_02755) 554399..555880 + 1482 WP_009330132.1 PH domain-containing protein -
OSR41_RS02760 (OSR41_02760) 555877..556476 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
OSR41_RS02765 (OSR41_02765) 556819..557778 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
OSR41_RS02770 (OSR41_02770) 558003..559172 + 1170 WP_026080763.1 alanine racemase -
OSR41_RS02775 (OSR41_02775) 559284..559565 + 282 WP_006638778.1 hypothetical protein Antitoxin
OSR41_RS02780 (OSR41_02780) 559570..559920 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OSR41_RS02785 (OSR41_02785) 560038..560865 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
OSR41_RS02790 (OSR41_02790) 560869..561234 + 366 WP_003179132.1 STAS domain-containing protein -
OSR41_RS02795 (OSR41_02795) 561237..561638 + 402 WP_003179135.1 anti-sigma regulatory factor -
OSR41_RS02800 (OSR41_02800) 561649..562656 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
OSR41_RS02805 (OSR41_02805) 562715..563041 + 327 WP_003179140.1 anti-sigma factor antagonist -
OSR41_RS02810 (OSR41_02810) 563041..563526 + 486 WP_003179142.1 anti-sigma B factor RsbW -
OSR41_RS02815 (OSR41_02815) 563492..564283 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
OSR41_RS02820 (OSR41_02820) 564280..564879 + 600 WP_003179145.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T269515 WP_003179128.1 NZ_CP116941:559570-559920 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT269515 WP_006638778.1 NZ_CP116941:559284-559565 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References