269514

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2598776..2599427 Replicon chromosome
Accession NZ_CP116932
Organism Lacticaseibacillus rhamnosus GG

Toxin (Protein)


Gene name pemK Uniprot ID K8Q4Y0
Locus tag PP652_RS12145 Protein ID WP_005686631.1
Coordinates 2598776..2599159 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID K8QH19
Locus tag PP652_RS12150 Protein ID WP_005686632.1
Coordinates 2599179..2599427 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PP652_RS12140 (PP652_12140) 2597812..2598339 - 528 WP_005686630.1 QueT transporter family protein -
PP652_RS12145 (PP652_12145) 2598776..2599159 - 384 WP_005686631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PP652_RS12150 (PP652_12150) 2599179..2599427 - 249 WP_005686632.1 antitoxin Antitoxin
PP652_RS12155 (PP652_12155) 2599539..2600678 - 1140 WP_005686633.1 alanine racemase -
PP652_RS12160 (PP652_12160) 2600665..2601039 - 375 WP_005686634.1 holo-ACP synthase -
PP652_RS12165 (PP652_12165) 2601208..2602716 - 1509 WP_005686635.1 DEAD/DEAH box helicase -
PP652_RS12170 (PP652_12170) 2602990..2604378 - 1389 WP_015765066.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13757.03 Da        Isoelectric Point: 10.9764

>T269514 WP_005686631.1 NZ_CP116932:c2599159-2598776 [Lacticaseibacillus rhamnosus GG]
MDVTVKRGDVFFADLSPVVGSEQGGNRPVLIIQNNVGNHYSPTVIVAAITSKIQKPKMPTHVGLRAKQDGVERNSVILLE
QIRTIDKQRLQARVTALSSAKMAAVDRALAISVGLVSLPKPKTYNKN

Download         Length: 384 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8936.13 Da        Isoelectric Point: 4.4778

>AT269514 WP_005686632.1 NZ_CP116932:c2599427-2599179 [Lacticaseibacillus rhamnosus GG]
MKKETSVTVALDSAIKARLDAYCELNDMGVQDVITEAVAKFLQSQAPEINQLISGYVAMGQINTEISHAFSACESEAYAH
IR

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8Q4Y0

Antitoxin

Source ID Structure
AlphaFold DB K8QH19

References