Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3641699..3642317 Replicon chromosome
Accession NZ_CP116931
Organism Escherichia coli strain MLI106K1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL422_RS18240 Protein ID WP_001291435.1
Coordinates 3642099..3642317 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL422_RS18235 Protein ID WP_000344800.1
Coordinates 3641699..3642073 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL422_RS18225 (3636788) 3636788..3637981 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL422_RS18230 (3638004) 3638004..3641153 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL422_RS18235 (3641699) 3641699..3642073 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL422_RS18240 (3642099) 3642099..3642317 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL422_RS18245 (3642489) 3642489..3643040 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL422_RS18250 (3643156) 3643156..3643626 + 471 WP_000136192.1 YlaC family protein -
NL422_RS18255 (3643790) 3643790..3645340 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL422_RS18260 (3645382) 3645382..3645735 - 354 WP_001550741.1 DUF1428 family protein -
NL422_RS18270 (3646114) 3646114..3646425 + 312 WP_000409911.1 MGMT family protein -
NL422_RS18275 (3646456) 3646456..3647028 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269507 WP_001291435.1 NZ_CP116931:3642099-3642317 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269507 WP_000344800.1 NZ_CP116931:3641699-3642073 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References