Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3182693..3183398 Replicon chromosome
Accession NZ_CP116931
Organism Escherichia coli strain MLI106K1

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NL422_RS16095 Protein ID WP_000539521.1
Coordinates 3182693..3183079 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NL422_RS16100 Protein ID WP_001280945.1
Coordinates 3183069..3183398 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL422_RS16075 (3178697) 3178697..3179323 + 627 WP_001595548.1 glutathione S-transferase GstB -
NL422_RS16080 (3179320) 3179320..3180435 - 1116 WP_001595547.1 aldose sugar dehydrogenase YliI -
NL422_RS16085 (3180546) 3180546..3180929 - 384 WP_000497137.1 biofilm formation regulator BssR -
NL422_RS16090 (3181142) 3181142..3182467 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
NL422_RS16095 (3182693) 3182693..3183079 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL422_RS16100 (3183069) 3183069..3183398 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NL422_RS16105 (3183468) 3183468..3184796 - 1329 WP_049068068.1 GGDEF domain-containing protein -
NL422_RS16110 (3184804) 3184804..3187152 - 2349 WP_001328220.1 EAL domain-containing protein -
NL422_RS16115 (3187330) 3187330..3188241 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T269506 WP_000539521.1 NZ_CP116931:3182693-3183079 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT269506 WP_001280945.1 NZ_CP116931:3183069-3183398 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References