Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2928817..2929601 Replicon chromosome
Accession NZ_CP116931
Organism Escherichia coli strain MLI106K1

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag NL422_RS14895 Protein ID WP_000613626.1
Coordinates 2929107..2929601 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag NL422_RS14890 Protein ID WP_001110447.1
Coordinates 2928817..2929110 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL422_RS14880 (2923967) 2923967..2924926 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
NL422_RS14885 (2925499) 2925499..2928684 + 3186 WP_001550951.1 ribonuclease E -
NL422_RS14890 (2928817) 2928817..2929110 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
NL422_RS14895 (2929107) 2929107..2929601 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
NL422_RS14900 (2929696) 2929696..2930649 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
NL422_RS14905 (2930661) 2930661..2932304 - 1644 WP_072617246.1 flagellar hook-associated protein FlgK -
NL422_RS14910 (2932370) 2932370..2933311 - 942 WP_001366226.1 flagellar assembly peptidoglycan hydrolase FlgJ -
NL422_RS14915 (2933311) 2933311..2934408 - 1098 WP_001441925.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T269505 WP_000613626.1 NZ_CP116931:2929107-2929601 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT269505 WP_001110447.1 NZ_CP116931:2928817-2929110 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References