Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4115290..4115787 Replicon chromosome
Accession NZ_CP116929
Organism Escherichia coli strain MLI105

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL421_RS20340 Protein ID WP_001173343.1
Coordinates 4115290..4115463 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NL421_RS20345 Protein ID WP_114427757.1
Coordinates 4115491..4115787 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL421_RS20330 (4111960) 4111960..4113417 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL421_RS20335 (4113654) 4113654..4115171 + 1518 WP_047654388.1 lysine--tRNA ligase -
NL421_RS20340 (4115290) 4115290..4115463 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL421_RS20345 (4115491) 4115491..4115787 - 297 WP_114427757.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL421_RS20350 (4116014) 4116014..4116286 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NL421_RS20355 (4116298) 4116298..4116528 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NL421_RS20360 (4116709) 4116709..4118340 + 1632 WP_001216477.1 sensor histidine kinase -
NL421_RS20365 (4118337) 4118337..4119056 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269491 WP_001173343.1 NZ_CP116929:c4115463-4115290 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11409.94 Da        Isoelectric Point: 4.2544

>AT269491 WP_114427757.1 NZ_CP116929:c4115787-4115491 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDGYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References