Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2330287..2330925 Replicon chromosome
Accession NZ_CP116929
Organism Escherichia coli strain MLI105

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag NL421_RS11545 Protein ID WP_001447010.1
Coordinates 2330749..2330925 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NL421_RS11540 Protein ID WP_001270286.1
Coordinates 2330287..2330703 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL421_RS11520 (2325439) 2325439..2326380 - 942 WP_001251304.1 ABC transporter permease -
NL421_RS11525 (2326381) 2326381..2327394 - 1014 WP_047654399.1 ABC transporter ATP-binding protein -
NL421_RS11530 (2327412) 2327412..2328557 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NL421_RS11535 (2328802) 2328802..2330208 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
NL421_RS11540 (2330287) 2330287..2330703 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NL421_RS11545 (2330749) 2330749..2330925 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NL421_RS11550 (2331147) 2331147..2331377 + 231 WP_000494244.1 YncJ family protein -
NL421_RS11555 (2331469) 2331469..2333430 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NL421_RS11560 (2333503) 2333503..2334039 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NL421_RS11565 (2334131) 2334131..2335306 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T269485 WP_001447010.1 NZ_CP116929:c2330925-2330749 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT269485 WP_001270286.1 NZ_CP116929:c2330703-2330287 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References