Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4428307..4428804 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL420_RS22700 Protein ID WP_001173343.1
Coordinates 4428307..4428480 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NL420_RS22705 Protein ID WP_255055505.1
Coordinates 4428508..4428804 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS22690 (4424977) 4424977..4426434 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL420_RS22695 (4426671) 4426671..4428188 + 1518 WP_072667412.1 lysine--tRNA ligase -
NL420_RS22700 (4428307) 4428307..4428480 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL420_RS22705 (4428508) 4428508..4428804 - 297 WP_255055505.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL420_RS22710 (4429031) 4429031..4429303 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
NL420_RS22715 (4429315) 4429315..4429545 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
NL420_RS22720 (4429726) 4429726..4431357 + 1632 WP_001216477.1 sensor histidine kinase -
NL420_RS22725 (4431354) 4431354..4432073 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269471 WP_001173343.1 NZ_CP116925:c4428480-4428307 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11453.95 Da        Isoelectric Point: 4.1705

>AT269471 WP_255055505.1 NZ_CP116925:c4428804-4428508 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLVRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References