Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3619836..3620454 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL420_RS18655 Protein ID WP_001291435.1
Coordinates 3620236..3620454 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL420_RS18650 Protein ID WP_000344800.1
Coordinates 3619836..3620210 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS18640 (3614925) 3614925..3616118 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL420_RS18645 (3616141) 3616141..3619290 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL420_RS18650 (3619836) 3619836..3620210 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL420_RS18655 (3620236) 3620236..3620454 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL420_RS18660 (3620626) 3620626..3621177 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL420_RS18665 (3621293) 3621293..3621763 + 471 WP_000136192.1 YlaC family protein -
NL420_RS18670 (3621927) 3621927..3623477 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL420_RS18675 (3623519) 3623519..3623872 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL420_RS18685 (3624251) 3624251..3624562 + 312 WP_000409911.1 MGMT family protein -
NL420_RS18690 (3624593) 3624593..3625165 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269467 WP_001291435.1 NZ_CP116925:3620236-3620454 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269467 WP_000344800.1 NZ_CP116925:3619836-3620210 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References