Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2373595..2374121 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NL420_RS12355 Protein ID WP_000323025.1
Coordinates 2373834..2374121 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NL420_RS12350 Protein ID WP_000534858.1
Coordinates 2373595..2373834 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS12310 (2368838) 2368838..2369259 + 422 Protein_2305 hypothetical protein -
NL420_RS12315 (2369894) 2369894..2370265 + 372 WP_001406656.1 helix-turn-helix domain-containing protein -
NL420_RS12320 (2370303) 2370303..2370965 + 663 Protein_2307 ISNCY family transposase -
NL420_RS12325 (2371086) 2371086..2371235 + 150 WP_011443592.1 protein YdfW -
NL420_RS12330 (2371672) 2371672..2372004 - 333 Protein_2309 FlxA-like family protein -
NL420_RS12335 (2371895) 2371895..2372188 - 294 WP_255055842.1 hypothetical protein -
NL420_RS12340 (2372267) 2372267..2372332 - 66 Protein_2311 hypothetical protein -
NL420_RS12345 (2373385) 2373385..2373570 - 186 Protein_2312 protein YdfV -
NL420_RS12350 (2373595) 2373595..2373834 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NL420_RS12355 (2373834) 2373834..2374121 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NL420_RS12360 (2374193) 2374193..2374348 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
NL420_RS12365 (2374565) 2374565..2374816 + 252 WP_001463433.1 protein Rem -
NL420_RS12370 (2374883) 2374883..2375161 + 279 WP_001515373.1 hypothetical protein -
NL420_RS12375 (2375163) 2375163..2376095 + 933 WP_272782097.1 hypothetical protein -
NL420_RS12380 (2376373) 2376373..2376462 - 90 WP_120795389.1 hypothetical protein -
NL420_RS12385 (2376517) 2376517..2376729 - 213 WP_000087756.1 cold shock-like protein CspF -
NL420_RS12390 (2377030) 2377030..2377245 + 216 WP_000066484.1 cold shock-like protein CspB -
NL420_RS12395 (2377609) 2377609..2377779 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
NL420_RS12400 (2378000) 2378000..2378215 + 216 WP_001515371.1 phage lysis protein EssD -
NL420_RS12405 (2378220) 2378220..2378534 + 315 WP_001515370.1 YdfR family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2352242..2403905 51663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T269464 WP_000323025.1 NZ_CP116925:2373834-2374121 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT269464 WP_000534858.1 NZ_CP116925:2373595-2373834 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References