Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 740009..740844 Replicon chromosome
Accession NZ_CP116925
Organism Escherichia coli strain MLI104K2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag NL420_RS04190 Protein ID WP_000854821.1
Coordinates 740009..740386 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag NL420_RS04195 Protein ID WP_001285610.1
Coordinates 740476..740844 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL420_RS04165 (736398) 736398..737801 + 1404 Protein_713 inorganic phosphate transporter PitB -
NL420_RS04170 (737845) 737845..738381 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
NL420_RS04175 (738663) 738663..739505 - 843 WP_255123414.1 DUF4942 domain-containing protein -
NL420_RS04180 (739590) 739590..739787 - 198 WP_085949090.1 DUF957 domain-containing protein -
NL420_RS04185 (739815) 739815..740012 - 198 Protein_717 DUF5983 family protein -
NL420_RS04190 (740009) 740009..740386 - 378 WP_000854821.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NL420_RS04195 (740476) 740476..740844 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL420_RS04200 (740924) 740924..741145 - 222 WP_000692350.1 DUF987 domain-containing protein -
NL420_RS04205 (741232) 741232..741708 - 477 WP_001318130.1 RadC family protein -
NL420_RS04210 (741723) 741723..741893 - 171 Protein_722 antirestriction protein -
NL420_RS04215 (741895) 741895..744377 - 2483 Protein_723 AIDA repeat-containing protein -
NL420_RS04220 (744711) 744711..745583 - 873 WP_001069668.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T269455 WP_000854821.1 NZ_CP116925:c740386-740009 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT269455 WP_001285610.1 NZ_CP116925:c740844-740476 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54

Antitoxin

Source ID Structure

References