Detailed information of TA system TA026945

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1550325..1551679
• Replicon: chromosome
• Accession: NC_017531
• Organism: Pantoea ananatis AJ13355

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0H3L3I8
• Locus tag: PAJ_RS07110
• Protein ID: WP_014593755.1
• Coordinates: 1550325..1551440 (-)
• Length: 372 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PAJ_RS07115
• Protein ID: WP_014593756.1
• Coordinates: 1551440..1551679 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PAJ_RS07100	1547557..1549425	+	1869	WP_013025825.1	low affinity potassium transporter Kup	-
PAJ_RS07105	1549867..1550262	+	396	WP_041930803.1	GFA family protein	-
PAJ_RS07110	1550325..1551440	-	1116	WP_014593755.1	HipA domain-containing protein	Toxin
PAJ_RS07115	1551440..1551679	-	240	WP_014593756.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
PAJ_RS07120	1551794..1552237	+	444	WP_013025829.1	GNAT family N-acetyltransferase	-
PAJ_RS07125	1552301..1554677	-	2377	Protein_1403	glycoside hydrolase family 3 C-terminal domain-containing protein	-
PAJ_RS07130	1554700..1556088	-	1389	WP_014593758.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (115-328)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 372 a.a.
• Molecular weight: 41154.52 Da
• Isoelectric Point: 7.6557

>T26945 WP_014593755.1 NC_017531:c1551440-1550325 [Pantoea ananatis AJ13355]
MAKLIAWINGERTGTLTLHHNGALHFQYDANWLQHPLARPLSLSLSLQRAAMHSEKVVHFFENLLYPSALIEKDFYPTHP
IKSCEVFATLQKVGHTLPGALSLLPAKRQPVAPDQVTHSIFTPADEAQQFDIDNAYLCLSLARELTIPVPDAVLVHENGI
RKLRTERYDRRWRHDGQHLYHLPEEDVCQALGVPLSGRDEQQGGPGIDDIMALLMGSSSAMKDREDMMRCLVFQWLTGIT
RVNAKHLSLLIARGGSFRLAPFKHLLSACPGLSLRTTDRRDFQLAMGVTGPEGKQHHIDAIGPAHFLALAGSVGFSQAAM
RQILAAFVPGLPAAIVKVRDSLPDDYPLTLADAVFSHAMMMLERVRQAIRG

Nucleotide

• Length: 1116 bp

>T26945 NC_017531:c1551440-1550325 [Pantoea ananatis AJ13355]
ATGGCAAAGCTCATTGCCTGGATAAACGGCGAGCGTACGGGAACGCTGACGCTGCATCACAACGGCGCGCTGCATTTCCA
GTATGACGCCAACTGGCTTCAGCATCCGCTTGCCAGACCTCTCTCGCTTTCGTTGTCCTTACAGCGCGCCGCGATGCATT
CTGAGAAAGTCGTGCACTTTTTCGAAAACCTTCTCTATCCCAGCGCGTTGATCGAAAAGGATTTTTACCCGACTCACCCG
ATAAAATCCTGTGAGGTCTTTGCAACATTGCAGAAAGTGGGACACACATTACCCGGGGCGCTCAGTCTGCTGCCGGCAAA
GCGGCAGCCCGTCGCGCCGGACCAGGTAACGCACAGCATCTTCACCCCCGCCGATGAGGCACAGCAGTTCGATATCGATA
ATGCGTATCTGTGTCTGTCCCTGGCCCGGGAGCTGACTATCCCGGTGCCGGATGCCGTGTTAGTTCATGAGAACGGCATC
CGTAAATTGAGAACAGAACGATACGATCGCCGTTGGCGTCACGACGGACAACACCTTTATCATCTTCCCGAAGAAGACGT
GTGTCAGGCGCTCGGCGTGCCGCTCTCTGGCCGCGATGAGCAGCAGGGCGGTCCGGGAATTGATGACATCATGGCCTTGC
TGATGGGCTCAAGCTCCGCCATGAAAGACCGTGAGGATATGATGCGCTGTCTGGTATTTCAGTGGCTGACGGGCATCACG
CGCGTCAACGCTAAACATCTCTCGCTGCTGATTGCTCGCGGTGGCAGCTTCCGGCTCGCGCCTTTTAAGCATCTCCTTTC
CGCCTGCCCGGGGCTTTCTCTGCGCACAACAGACAGACGGGATTTCCAGCTGGCGATGGGCGTGACAGGCCCTGAGGGCA
AACAGCATCACATTGACGCGATTGGGCCCGCGCATTTTCTTGCCCTTGCGGGGAGCGTGGGGTTCAGTCAGGCAGCGATG
CGGCAGATACTGGCGGCCTTTGTTCCGGGCTTGCCTGCCGCGATTGTTAAGGTGCGGGACAGCCTGCCCGATGATTATCC
CCTGACGCTCGCCGATGCGGTTTTCAGCCACGCAATGATGATGCTGGAAAGGGTACGCCAGGCGATCCGAGGTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8790.95 Da
• Isoelectric Point: 6.4540

>AT26945 WP_014593756.1 NC_017531:c1551679-1551440 [Pantoea ananatis AJ13355]
MIYSPRQLANQVRLLRQQNGWTQVELAKKVGLKQATLSHFENAPDTTSLATLFKILQALDLALSLHENSASSAPDEDAW

Nucleotide

• Length: 240 bp

>AT26945 NC_017531:c1551679-1551440 [Pantoea ananatis AJ13355]
ATGATTTACAGTCCCCGCCAGTTGGCGAATCAGGTCAGGCTATTGCGGCAGCAAAACGGCTGGACCCAGGTCGAACTGGC
GAAAAAAGTGGGCCTGAAACAGGCAACCCTGTCTCACTTCGAAAATGCCCCGGATACAACCTCACTGGCAACGTTGTTCA
AAATCTTACAGGCGCTCGATCTTGCTCTGTCGCTTCATGAAAACAGCGCATCCTCAGCCCCGGATGAGGATGCCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3L3I8