269443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yafW-ykfI/CbtA-CbeA
Location 3669075..3669754 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name ykfI Uniprot ID S1FHS4
Locus tag NL419_RS18655 Protein ID WP_000854680.1
Coordinates 3669413..3669754 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID -
Locus tag NL419_RS18650 Protein ID WP_097463457.1
Coordinates 3669075..3669392 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL419_RS18605 (3664513) 3664513..3665334 + 822 WP_032200808.1 DUF932 domain-containing protein -
NL419_RS18610 (3665551) 3665551..3666252 + 702 WP_001581462.1 WYL domain-containing protein -
NL419_RS18615 (3666293) 3666293..3666529 + 237 WP_001144031.1 protein YpjK -
NL419_RS18620 (3666529) 3666529..3666972 + 444 WP_032199444.1 lipoprotein YafY -
NL419_RS18625 (3666995) 3666995..3667462 + 468 WP_032200803.1 protein YkfB -
NL419_RS18630 (3667539) 3667539..3667778 + 240 WP_000194654.1 DUF905 family protein -
NL419_RS18635 (3667876) 3667876..3668334 + 459 WP_032177818.1 antirestriction protein -
NL419_RS18640 (3668350) 3668350..3668826 + 477 WP_072667534.1 RadC family protein -
NL419_RS18645 (3668835) 3668835..3669056 + 222 WP_063928002.1 DUF987 domain-containing protein -
NL419_RS18650 (3669075) 3669075..3669392 + 318 WP_097463457.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NL419_RS18655 (3669413) 3669413..3669754 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI Toxin
NL419_RS18660 (3670417) 3670417..3670629 + 213 Protein_3560 integrase core domain-containing protein -
NL419_RS18665 (3670671) 3670671..3671414 - 744 WP_032170462.1 AraC family transcriptional regulator -
NL419_RS18675 (3672675) 3672675..3672962 - 288 Protein_3563 hypothetical protein -
NL419_RS18680 (3673124) 3673124..3673180 + 57 WP_211180520.1 protein YsgD -
NL419_RS18685 (3673332) 3673332..3674282 + 951 WP_000947148.1 magnesium/cobalt transporter CorA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3667876..3712539 44663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12892.95 Da        Isoelectric Point: 9.6543

>T269443 WP_000854680.1 NZ_CP116923:3669413-3669754 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11940.54 Da        Isoelectric Point: 7.0267

>AT269443 WP_097463457.1 NZ_CP116923:3669075-3669392 [Escherichia coli]
MSNITWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDAECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHS4

Antitoxin

Source ID Structure

References