Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3475387..3476005 Replicon chromosome
Accession NZ_CP116923
Organism Escherichia coli strain MLI104K1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL419_RS17680 Protein ID WP_001291435.1
Coordinates 3475787..3476005 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL419_RS17675 Protein ID WP_000344800.1
Coordinates 3475387..3475761 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL419_RS17665 (3470476) 3470476..3471669 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL419_RS17670 (3471692) 3471692..3474841 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL419_RS17675 (3475387) 3475387..3475761 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL419_RS17680 (3475787) 3475787..3476005 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL419_RS17685 (3476177) 3476177..3476728 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL419_RS17690 (3476844) 3476844..3477314 + 471 WP_000136192.1 YlaC family protein -
NL419_RS17695 (3477478) 3477478..3479028 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL419_RS17700 (3479070) 3479070..3479423 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL419_RS17710 (3479802) 3479802..3480113 + 312 WP_000409911.1 MGMT family protein -
NL419_RS17715 (3480144) 3480144..3480716 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269442 WP_001291435.1 NZ_CP116923:3475787-3476005 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269442 WP_000344800.1 NZ_CP116923:3475387-3475761 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References