Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4632348..4632943 Replicon chromosome
Accession NZ_CP116919
Organism Escherichia coli strain MLI102

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag NL418_RS23415 Protein ID WP_019842229.1
Coordinates 4632348..4632698 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag NL418_RS23420 Protein ID WP_001223213.1
Coordinates 4632692..4632943 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL418_RS23395 (4627678) 4627678..4628700 - 1023 WP_001550507.1 ABC transporter permease -
NL418_RS23400 (4628714) 4628714..4630216 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
NL418_RS23405 (4630348) 4630348..4631304 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NL418_RS23410 (4631614) 4631614..4632144 + 531 WP_000055075.1 inorganic diphosphatase -
NL418_RS23415 (4632348) 4632348..4632698 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
NL418_RS23420 (4632692) 4632692..4632943 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NL418_RS23425 (4633155) 4633155..4633496 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
NL418_RS23430 (4633499) 4633499..4637278 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T269426 WP_019842229.1 NZ_CP116919:c4632698-4632348 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT269426 WP_001223213.1 NZ_CP116919:c4632943-4632692 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References