Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4620688..4621210 Replicon chromosome
Accession NZ_CP116919
Organism Escherichia coli strain MLI102

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NL418_RS23355 Protein ID WP_001105433.1
Coordinates 4620688..4620978 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NL418_RS23360 Protein ID WP_000212715.1
Coordinates 4620968..4621210 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL418_RS23340 (4615856) 4615856..4617511 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
NL418_RS23345 (4617905) 4617905..4620043 + 2139 WP_255073496.1 anaerobic ribonucleoside-triphosphate reductase -
NL418_RS23350 (4620223) 4620223..4620687 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL418_RS23355 (4620688) 4620688..4620978 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL418_RS23360 (4620968) 4620968..4621210 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL418_RS23365 (4621402) 4621402..4621788 - 387 WP_001232246.1 cytochrome b562 -
NL418_RS23370 (4621969) 4621969..4623321 - 1353 WP_001162173.1 metalloprotease PmbA -
NL418_RS23375 (4623415) 4623415..4623966 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NL418_RS23380 (4624116) 4624116..4625489 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T269425 WP_001105433.1 NZ_CP116919:c4620978-4620688 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT269425 WP_000212715.1 NZ_CP116919:c4621210-4620968 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References