Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3784315..3784933 Replicon chromosome
Accession NZ_CP116919
Organism Escherichia coli strain MLI102

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL418_RS19300 Protein ID WP_001291435.1
Coordinates 3784715..3784933 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL418_RS19295 Protein ID WP_000344800.1
Coordinates 3784315..3784689 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL418_RS19285 (3779404) 3779404..3780597 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL418_RS19290 (3780620) 3780620..3783769 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NL418_RS19295 (3784315) 3784315..3784689 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL418_RS19300 (3784715) 3784715..3784933 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL418_RS19305 (3785105) 3785105..3785656 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL418_RS19310 (3785772) 3785772..3786242 + 471 WP_000136192.1 YlaC family protein -
NL418_RS19315 (3786406) 3786406..3787956 + 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL418_RS19320 (3787998) 3787998..3788351 - 354 WP_001550741.1 DUF1428 family protein -
NL418_RS19330 (3788730) 3788730..3789041 + 312 WP_000409911.1 MGMT family protein -
NL418_RS19335 (3789072) 3789072..3789644 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269423 WP_001291435.1 NZ_CP116919:3784715-3784933 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269423 WP_000344800.1 NZ_CP116919:3784315-3784689 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References