Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4161040..4161537 Replicon chromosome
Accession NZ_CP116916
Organism Escherichia coli strain MLI023K2

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL417_RS21150 Protein ID WP_001173343.1
Coordinates 4161040..4161213 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NL417_RS21155 Protein ID WP_072280288.1
Coordinates 4161241..4161537 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL417_RS21140 (4157705) 4157705..4159162 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL417_RS21145 (4159399) 4159399..4160916 + 1518 WP_001295074.1 lysine--tRNA ligase -
NL417_RS21150 (4161040) 4161040..4161213 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL417_RS21155 (4161241) 4161241..4161537 - 297 WP_072280288.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL417_RS21160 (4161764) 4161764..4162036 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NL417_RS21165 (4162048) 4162048..4162278 - 231 WP_044782310.1 4Fe-4S mono-cluster protein YjdI -
NL417_RS21170 (4162459) 4162459..4164090 + 1632 WP_001216477.1 sensor histidine kinase -
NL417_RS21175 (4164087) 4164087..4164806 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4137379..4161537 24158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269410 WP_001173343.1 NZ_CP116916:c4161213-4161040 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11482.00 Da        Isoelectric Point: 4.1705

>AT269410 WP_072280288.1 NZ_CP116916:c4161537-4161241 [Escherichia coli]
MEGKNKFNTYIVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References