Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3937557..3938133 Replicon chromosome
Accession NZ_CP116916
Organism Escherichia coli strain MLI023K2

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag NL417_RS20050 Protein ID WP_001297643.1
Coordinates 3937846..3938133 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag NL417_RS20045 Protein ID WP_061358923.1
Coordinates 3937557..3937859 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL417_RS20030 (3934153) 3934153..3936303 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
NL417_RS20035 (3936353) 3936353..3936556 + 204 WP_000467859.1 YbdD/YjiX family protein -
NL417_RS20040 (3936567) 3936567..3937523 + 957 WP_001297640.1 GTPase -
NL417_RS20045 (3937557) 3937557..3937859 - 303 WP_061358923.1 BrnA antitoxin family protein Antitoxin
NL417_RS20050 (3937846) 3937846..3938133 - 288 WP_001297643.1 BrnT family toxin Toxin
NL417_RS20055 (3938332) 3938332..3939029 - 698 Protein_3774 IS1 family transposase -
NL417_RS20060 (3939344) 3939344..3940576 + 1233 WP_001137031.1 multidrug efflux MFS transporter MdtM -
NL417_RS20065 (3940617) 3940617..3941897 + 1281 WP_061358924.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3938332..3938541 209


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T269409 WP_001297643.1 NZ_CP116916:c3938133-3937846 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11550.04 Da        Isoelectric Point: 9.4646

>AT269409 WP_061358923.1 NZ_CP116916:c3937859-3937557 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNVERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure

References