Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3398617..3399235 Replicon chromosome
Accession NZ_CP116916
Organism Escherichia coli strain MLI023K2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL417_RS17420 Protein ID WP_001291435.1
Coordinates 3399017..3399235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL417_RS17415 Protein ID WP_000344800.1
Coordinates 3398617..3398991 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL417_RS17405 (3393706) 3393706..3394899 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL417_RS17410 (3394922) 3394922..3398071 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL417_RS17415 (3398617) 3398617..3398991 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL417_RS17420 (3399017) 3399017..3399235 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL417_RS17425 (3399407) 3399407..3399958 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL417_RS17430 (3400074) 3400074..3400544 + 471 WP_000136192.1 YlaC family protein -
NL417_RS17435 (3400708) 3400708..3402258 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL417_RS17440 (3402300) 3402300..3402653 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL417_RS17450 (3403032) 3403032..3403343 + 312 WP_000409911.1 MGMT family protein -
NL417_RS17455 (3403374) 3403374..3403946 - 573 WP_101800724.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269407 WP_001291435.1 NZ_CP116916:3399017-3399235 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269407 WP_000344800.1 NZ_CP116916:3398617-3398991 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References