Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 819779..820433 Replicon chromosome
Accession NZ_CP116916
Organism Escherichia coli strain MLI023K2

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NL417_RS04780 Protein ID WP_000244781.1
Coordinates 820026..820433 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NL417_RS04775 Protein ID WP_000354046.1
Coordinates 819779..820045 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL417_RS04750 (814948) 814948..815691 + 744 WP_000951964.1 SDR family oxidoreductase -
NL417_RS04755 (815748) 815748..817181 - 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
NL417_RS04760 (817226) 817226..817537 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
NL417_RS04765 (817701) 817701..818360 + 660 WP_000250274.1 hemolysin III family protein -
NL417_RS04770 (818556) 818556..819536 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
NL417_RS04775 (819779) 819779..820045 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NL417_RS04780 (820026) 820026..820433 + 408 WP_000244781.1 protein YgfX Toxin
NL417_RS04785 (820473) 820473..820994 - 522 WP_001055874.1 flavodoxin FldB -
NL417_RS04790 (821106) 821106..822002 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NL417_RS04795 (822027) 822027..822737 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL417_RS04800 (822743) 822743..824476 + 1734 WP_000813201.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T269399 WP_000244781.1 NZ_CP116916:820026-820433 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT269399 WP_000354046.1 NZ_CP116916:819779-820045 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References