Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4160263..4160760 Replicon chromosome
Accession NZ_CP116913
Organism Escherichia coli strain MLI023K1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NL406_RS21135 Protein ID WP_001173343.1
Coordinates 4160263..4160436 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NL406_RS21140 Protein ID WP_072280288.1
Coordinates 4160464..4160760 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL406_RS21125 (4156928) 4156928..4158385 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NL406_RS21130 (4158622) 4158622..4160139 + 1518 WP_001295074.1 lysine--tRNA ligase -
NL406_RS21135 (4160263) 4160263..4160436 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NL406_RS21140 (4160464) 4160464..4160760 - 297 WP_072280288.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NL406_RS21145 (4160987) 4160987..4161259 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
NL406_RS21150 (4161271) 4161271..4161501 - 231 WP_044782310.1 4Fe-4S mono-cluster protein YjdI -
NL406_RS21155 (4161682) 4161682..4163313 + 1632 WP_001216477.1 sensor histidine kinase -
NL406_RS21160 (4163310) 4163310..4164029 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4136602..4160760 24158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T269394 WP_001173343.1 NZ_CP116913:c4160436-4160263 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11482.00 Da        Isoelectric Point: 4.1705

>AT269394 WP_072280288.1 NZ_CP116913:c4160760-4160464 [Escherichia coli]
MEGKNKFNTYIVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References