Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3936780..3937356 Replicon chromosome
Accession NZ_CP116913
Organism Escherichia coli strain MLI023K1

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag NL406_RS20035 Protein ID WP_001297643.1
Coordinates 3937069..3937356 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag NL406_RS20030 Protein ID WP_061358923.1
Coordinates 3936780..3937082 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL406_RS20015 (3933376) 3933376..3935526 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
NL406_RS20020 (3935576) 3935576..3935779 + 204 WP_000467859.1 YbdD/YjiX family protein -
NL406_RS20025 (3935790) 3935790..3936746 + 957 WP_001297640.1 GTPase -
NL406_RS20030 (3936780) 3936780..3937082 - 303 WP_061358923.1 BrnA antitoxin family protein Antitoxin
NL406_RS20035 (3937069) 3937069..3937356 - 288 WP_001297643.1 BrnT family toxin Toxin
NL406_RS20040 (3937555) 3937555..3938252 - 698 Protein_3771 IS1 family transposase -
NL406_RS20045 (3938567) 3938567..3939799 + 1233 WP_001137031.1 multidrug efflux MFS transporter MdtM -
NL406_RS20050 (3939840) 3939840..3941120 + 1281 WP_061358924.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T269393 WP_001297643.1 NZ_CP116913:c3937356-3937069 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11550.04 Da        Isoelectric Point: 9.4646

>AT269393 WP_061358923.1 NZ_CP116913:c3937082-3936780 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNVERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure

References