Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3397838..3398456 Replicon chromosome
Accession NZ_CP116913
Organism Escherichia coli strain MLI023K1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NL406_RS17405 Protein ID WP_001291435.1
Coordinates 3398238..3398456 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NL406_RS17400 Protein ID WP_000344800.1
Coordinates 3397838..3398212 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL406_RS17390 (3392927) 3392927..3394120 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL406_RS17395 (3394143) 3394143..3397292 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NL406_RS17400 (3397838) 3397838..3398212 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NL406_RS17405 (3398238) 3398238..3398456 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NL406_RS17410 (3398628) 3398628..3399179 + 552 WP_000102564.1 maltose O-acetyltransferase -
NL406_RS17415 (3399295) 3399295..3399765 + 471 WP_000136192.1 YlaC family protein -
NL406_RS17420 (3399929) 3399929..3401479 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NL406_RS17425 (3401521) 3401521..3401874 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NL406_RS17435 (3402253) 3402253..3402564 + 312 WP_000409911.1 MGMT family protein -
NL406_RS17440 (3402595) 3402595..3403167 - 573 WP_101800724.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T269391 WP_001291435.1 NZ_CP116913:3398238-3398456 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT269391 WP_000344800.1 NZ_CP116913:3397838-3398212 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References