Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 872944..873720 Replicon chromosome
Accession NZ_CP116909
Organism Staphylococcus aureus strain AATYW

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LOY12_RS04675 Protein ID WP_000031108.1
Coordinates 873568..873720 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LOY12_RS04670 Protein ID WP_001251224.1
Coordinates 872944..873543 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY12_RS04650 (868860) 868860..870317 + 1458 WP_000649908.1 ABC transporter permease subunit -
LOY12_RS04655 (870310) 870310..871032 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LOY12_RS04660 (871183) 871183..872310 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LOY12_RS04665 (872315) 872315..872785 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LOY12_RS04670 (872944) 872944..873543 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LOY12_RS04675 (873568) 873568..873720 + 153 WP_000031108.1 SAS053 family protein Toxin
LOY12_RS04680 (874268) 874268..874663 + 396 WP_000901023.1 hypothetical protein -
LOY12_RS04685 (874859) 874859..876244 + 1386 WP_016170518.1 class II fumarate hydratase -
LOY12_RS04690 (876697) 876697..877518 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T269376 WP_000031108.1 NZ_CP116909:873568-873720 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT269376 WP_001251224.1 NZ_CP116909:872944-873543 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References