Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 660846..661375 Replicon chromosome
Accession NZ_CP116909
Organism Staphylococcus aureus strain AATYW

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LOY12_RS03285 Protein ID WP_000621175.1
Coordinates 661013..661375 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LOY12_RS03280 Protein ID WP_000948331.1
Coordinates 660846..661016 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY12_RS03250 (655883) 655883..656443 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
LOY12_RS03255 (656651) 656651..657130 + 480 WP_001287087.1 hypothetical protein -
LOY12_RS03260 (657123) 657123..658706 + 1584 WP_001294626.1 PH domain-containing protein -
LOY12_RS03265 (658693) 658693..659184 + 492 WP_001205912.1 PH domain-containing protein -
LOY12_RS03270 (659188) 659188..659547 + 360 WP_000581197.1 holo-ACP synthase -
LOY12_RS03275 (659613) 659613..660761 + 1149 WP_054194470.1 alanine racemase -
LOY12_RS03280 (660846) 660846..661016 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LOY12_RS03285 (661013) 661013..661375 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LOY12_RS03290 (661725) 661725..662726 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LOY12_RS03295 (662845) 662845..663171 + 327 WP_001052491.1 anti-sigma factor antagonist -
LOY12_RS03300 (663173) 663173..663652 + 480 WP_001190829.1 anti-sigma B factor RsbW -
LOY12_RS03305 (663627) 663627..664397 + 771 WP_001041111.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T269371 WP_000621175.1 NZ_CP116909:661013-661375 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT269371 WP_000948331.1 NZ_CP116909:660846-661016 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References