Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 641122..641636 Replicon chromosome
Accession NZ_CP116909
Organism Staphylococcus aureus strain AATYW

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LOY12_RS03195 Protein ID WP_000581792.1
Coordinates 641427..641636 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LOY12_RS03190 Protein ID WP_000138932.1
Coordinates 641122..641415 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY12_RS03170 (636285) 636285..636926 + 642 WP_000483153.1 thiamine phosphate synthase -
LOY12_RS03175 (637012) 637012..637884 + 873 WP_000725802.1 membrane protein insertase YidC -
LOY12_RS03180 (638797) 638797..639444 - 648 WP_001187630.1 HD domain-containing protein -
LOY12_RS03185 (639472) 639472..640956 - 1485 WP_000571549.1 cardiolipin synthase -
LOY12_RS03190 (641122) 641122..641415 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LOY12_RS03195 (641427) 641427..641636 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LOY12_RS03200 (641764) 641764..641901 + 138 WP_000828354.1 Lmo0850 family protein -
LOY12_RS03205 (642165) 642165..643367 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LOY12_RS03210 (643685) 643685..644755 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LOY12_RS03215 (644770) 644770..646128 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T269370 WP_000581792.1 NZ_CP116909:641427-641636 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT269370 WP_000138932.1 NZ_CP116909:641122-641415 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References