Detailed information of TA system TA026937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3702019..3702693
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: MTCTRI2_RS17535
• Protein ID: WP_003417282.1
• Coordinates: 3702019..3702447 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: MTCTRI2_RS17540
• Protein ID: WP_003417286.1
• Coordinates: 3702451..3702693 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS17510	3697841..3698242	-	402	WP_003417264.1	cytidine deaminase	-
MTCTRI2_RS17515	3698383..3698817	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
MTCTRI2_RS17520	3698814..3699248	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
MTCTRI2_RS17525	3699377..3701149	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
MTCTRI2_RS17530	3701149..3701940	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
MTCTRI2_RS17535	3702019..3702447	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTCTRI2_RS17540	3702451..3702693	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
MTCTRI2_RS17545	3702815..3703429	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
MTCTRI2_RS17550	3703426..3704091	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
MTCTRI2_RS17555	3704092..3704625	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
MTCTRI2_RS17560	3704622..3704996	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
MTCTRI2_RS17575	3706451..3707515	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T26937 WP_003417282.1 NC_017524:c3702447-3702019 [Mycobacterium tuberculosis CTRI-2]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T26937 NC_017524:c3702447-3702019 [Mycobacterium tuberculosis CTRI-2]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT26937 WP_003417286.1 NC_017524:c3702693-3702451 [Mycobacterium tuberculosis CTRI-2]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT26937 NC_017524:c3702693-3702451 [Mycobacterium tuberculosis CTRI-2]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59