Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 267097..267620 Replicon chromosome
Accession NZ_CP116909
Organism Staphylococcus aureus strain AATYW

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag LOY12_RS01260 Protein ID WP_000074049.1
Coordinates 267354..267620 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LOY12_RS01255 Protein ID WP_000587616.1
Coordinates 267097..267354 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY12_RS01240 (263594) 263594..264343 - 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -
LOY12_RS01245 (264538) 264538..266115 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
LOY12_RS01250 (266283) 266283..266738 - 456 WP_000732076.1 DUF1307 domain-containing protein -
LOY12_RS01255 (267097) 267097..267354 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LOY12_RS01260 (267354) 267354..267620 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
LOY12_RS01265 (267975) 267975..269051 + 1077 WP_001076673.1 M42 family metallopeptidase -
LOY12_RS01270 (269299) 269299..269961 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
LOY12_RS01275 (269954) 269954..270730 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
LOY12_RS01280 (271126) 271126..272313 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T269364 WP_000074049.1 NZ_CP116909:267354-267620 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT269364 WP_000587616.1 NZ_CP116909:267097-267354 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References