Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 9751..10331 Replicon plasmid pKP2722-4
Accession NZ_CP116907
Organism Klebsiella pneumoniae strain KP2722

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag PO783_RS30340 Protein ID WP_071177730.1
Coordinates 9751..10065 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag PO783_RS30345 Protein ID WP_000093040.1
Coordinates 10053..10331 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PO783_RS30315 (PO783_30315) 5695..7659 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
PO783_RS30320 (PO783_30320) 7659..8390 + 732 WP_071177728.1 MobC family replication-relaxation protein -
PO783_RS30325 (PO783_30325) 8397..8927 + 531 WP_071177729.1 hypothetical protein -
PO783_RS30330 (PO783_30330) 8954..9133 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
PO783_RS30335 (PO783_30335) 9159..9587 - 429 WP_001140599.1 hypothetical protein -
PO783_RS30340 (PO783_30340) 9751..10065 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PO783_RS30345 (PO783_30345) 10053..10331 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
PO783_RS30350 (PO783_30350) 10506..10871 - 366 WP_072354022.1 TonB family protein -
PO783_RS30355 (PO783_30355) 10868..11239 - 372 WP_001237044.1 cell envelope integrity protein TolA -
PO783_RS30360 (PO783_30360) 11513..11758 - 246 WP_032440458.1 hypothetical protein -
PO783_RS30365 (PO783_30365) 12403..13890 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23940 23940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T269362 WP_071177730.1 NZ_CP116907:c10065-9751 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT269362 WP_000093040.1 NZ_CP116907:c10331-10053 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References