Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 6977..7887 | Replicon | plasmid pKP2722-1 |
Accession | NZ_CP116904 | ||
Organism | Klebsiella pneumoniae strain KP2722 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A663AYG0 |
Locus tag | PO783_RS27975 | Protein ID | WP_004026354.1 |
Coordinates | 7417..7887 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | A0A6P1V3Q9 |
Locus tag | PO783_RS27970 | Protein ID | WP_004026357.1 |
Coordinates | 6977..7420 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PO783_RS27945 (PO783_27945) | 2225..3187 | + | 963 | WP_004902373.1 | DEAD/DEAH box helicase | - |
PO783_RS27950 (PO783_27950) | 3531..3752 | - | 222 | WP_004213615.1 | hypothetical protein | - |
PO783_RS27955 (PO783_27955) | 3814..5121 | - | 1308 | Protein_5 | FepA family TonB-dependent siderophore receptor | - |
PO783_RS27960 (PO783_27960) | 5187..6167 | + | 981 | WP_000019473.1 | IS5-like element ISKpn26 family transposase | - |
PO783_RS27965 (PO783_27965) | 6373..6876 | + | 504 | Protein_7 | DUF4113 domain-containing protein | - |
PO783_RS27970 (PO783_27970) | 6977..7420 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
PO783_RS27975 (PO783_27975) | 7417..7887 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
PO783_RS27980 (PO783_27980) | 8036..8733 | + | 698 | WP_223175001.1 | IS1-like element IS1A family transposase | - |
PO783_RS27985 (PO783_27985) | 8735..9184 | + | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
PO783_RS27990 (PO783_27990) | 9201..9512 | + | 312 | WP_011251282.1 | hypothetical protein | - |
PO783_RS27995 (PO783_27995) | 9526..9867 | + | 342 | WP_011251281.1 | hypothetical protein | - |
PO783_RS28000 (PO783_28000) | 9927..10883 | + | 957 | WP_011251280.1 | DsbA family protein | - |
PO783_RS28005 (PO783_28005) | 11308..11748 | - | 441 | WP_011251275.1 | hypothetical protein | - |
PO783_RS28010 (PO783_28010) | 11754..12248 | - | 495 | WP_011251274.1 | hypothetical protein | - |
PO783_RS28015 (PO783_28015) | 12257..12571 | - | 315 | WP_011251273.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA2 / iutA / iucD / iucC / iucB / iucA | 1..181653 | 181653 | |
- | inside | IScluster/Tn | - | iroN | 576..14168 | 13592 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T269352 WP_004026354.1 NZ_CP116904:7417-7887 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT269352 WP_004026357.1 NZ_CP116904:6977-7420 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A663AYG0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6P1V3Q9 |